SCHEMBL16689869

SCHEMBL16689869

Cc1cc(C)c(-c2ccccc2F)c(C)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.46
PDK2 Q15119 1/20 0.45
MBNL1 Q9NR56 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.40
NPC1 O15118 2/20 0.40
GAA P10253 2/20 0.40
RAB9A P51151 2/20 0.40
TNKS O95271 1/20 0.39
TNKS2 Q9H2K2 1/20 0.39
HSD11B1 P28845 1/20 0.39
GPR3 P46089 1/20 0.39
DHODH Q02127 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2A6 P11509 1/20 0.39
MGAM O43451 1/20 0.38
SI P14410 1/20 0.38
MGAM2 Q2M2H8 1/20 0.38
MEN1 O00255 1/20 0.38
NFKB1 P19838 1/20 0.38
NFKB2 Q00653 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1133195 0.82 ACHE (0.56) ACHEPDK2MBNL1SMN1; SMN2NPC1
SCHEMBL4265966 0.79 PDK2 (0.44) ACHEPDK2SMN1; SMN2NPC1GAA
SCHEMBL17407435 0.79 PDK2 (0.47) ACHEPDK2MBNL1SMN1; SMN2NPC1
SCHEMBL2599674 0.79 TNKS (0.41) ACHEMBNL1SMN1; SMN2NPC1GAA
SCHEMBL13601636 0.77 TTR (0.59) SMN1; SMN2NPC1RAB9ADHODH
SCHEMBL14850866 0.77 ELANE (0.45) ACHEPDK2MBNL1SMN1; SMN2NPC1
SCHEMBL9754458 0.76 PDK2 (0.35) ACHEPDK2TNKSTNKS2CYP1A2
SCHEMBL30659234 0.76 PTPRC (0.46) ACHEPDK2MBNL1SMN1; SMN2NPC1
SCHEMBL21280690 0.75 PDK2 (0.43) ACHEPDK2SMN1; SMN2NPC1RAB9A
SCHEMBL2558217 0.74 LMNA (0.47) PDK2SMN1; SMN2CYP1A2CYP2A6HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015063543-A1 HYDRIDOPALLADIUM(II) HALIDES AS PREFORMED CATALYSTS FOR SUZUKI-MIYAURA CROSS-COUPLING REACTIONS LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) 2015-05-07 WO disclosed