Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.69 |
| ▸ | DRD2 | P14416 | 5/20 | 0.69 |
| ▸ | DRD4 | P21917 | 3/20 | 0.69 |
| ▸ | HRH2 | P25021 | 2/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | HTR1B | P28222 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | HTR7 | P34969 | 1/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | HRH1 | P35367 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.69 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8038081 | 0.89 | DRD3 (0.69) | DRD3DRD2DRD4HRH2ADRA2A | |
| SCHEMBL28430172 | 0.88 | DRD3 (0.64) | DRD3DRD2DRD4HRH2ADRA2A | |
| SCHEMBL28430173 | 0.88 | DRD3 (0.64) | DRD3DRD2DRD4HRH2ADRA2A | |
| Hydrochloric Acid SCHEMBL7323381 | 0.87 | ADRA2A (0.54) | DRD3DRD2DRD4HRH2ADRA2A | |
| SCHEMBL4786177 | 0.83 | DRD3 (0.62) | DRD3DRD2DRD4HRH2ADRA2A | |
| SCHEMBL14146078 | 0.83 | DRD3 (0.62) | DRD3DRD2DRD4HRH2ADRA2A | |
| SCHEMBL17302433 | 0.83 | DRD3 (0.72) | DRD3DRD2DRD4HRH2ADRA2A | |
| SCHEMBL3981933 | 0.83 | DRD3 (0.72) | DRD3DRD2DRD4HRH2ADRA2A | |
| SCHEMBL5805250 | 0.82 | DRD3 (0.60) | DRD3DRD2DRD4HRH2ADRA2A | |
| SCHEMBL5709246 | 0.82 | DRD3 (0.71) | DRD3DRD2DRD4HRH2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208003-B2 | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds | KNOPP BIOSCIENCES LLC (US) | 2019-02-19 | — | — | US | disclosed |
| US-20170158648-A1 | SYNTHESIS OF AMINE SUBSTITUTED 4,5,6,7-TETRAHYDROBENZOTHIAZOLE COMPOUNDS | ARETEIA THERAPEUTICS, INC. | 2017-06-08 | — | — | US | disclosed |
| US-9512096-B2 | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds | Knopp Biosciences, LLP (US) | 2016-12-06 | — | — | US | disclosed |
| US-20150126745-A1 | SYNTHESIS OF AMINE SUBSTITUTED 4,5,6,7-TETRAHYDROBENZOTHIAZOLE COMPOUNDS | ARETEIA THERAPEUTICS, INC. | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158648-A1 | SYNTHESIS OF AMINE SUBSTITUTED 4,5,6,7-TETRAHYDROBENZOTHIAZOLE COMPOUNDS | TH, PAH, TPST2 | DRD3 1157/4885DRD2 525/4885DRD4 113/4885 |
| US-10208003-B2 | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds | TH, PAH, TPST2 | DRD3 1157/4885DRD2 525/4885DRD4 113/4885 |
| US-20150126745-A1 | SYNTHESIS OF AMINE SUBSTITUTED 4,5,6,7-TETRAHYDROBENZOTHIAZOLE COMPOUNDS | TH, PAH, TPST2 | DRD3 1157/4885DRD2 525/4885DRD4 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.