Sugi Predict

Sugi Predict / Compounds / SCHEMBL1669092

SCHEMBL1669092

SCHEMBL1669092

O=c1[nH]c2ccccc2c(=O)n1C[C@H]1CC[C@H](C(=O)O)CC1

nearest known ligand 0.70

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPK10 P53779 5/20 0.70
▸ HSD17B10 Q99714 2/20 0.70
▸ TSHR P16473 3/20 0.59
▸ HPGD P15428 5/20 0.55
▸ ALDH1A1 P00352 5/20 0.55
▸ KDM4E B2RXH2 3/20 0.55
▸ LMNA P02545 3/20 0.55
▸ SMN1; SMN2 Q16637 5/20 0.53
▸ MAPK1 P28482 1/20 0.53
▸ KMT2A Q03164 4/20 0.53
▸ MEN1 O00255 3/20 0.53
▸ ALOX12 P18054 1/20 0.52
▸ CYP1A2 P05177 1/20 0.51
▸ ACHE P22303 1/20 0.51
▸ MAPT P10636 2/20 0.50
▸ HTT P42858 2/20 0.50
▸ POLB P06746 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11893787 1.00 MAPK10 (0.70) MAPK10HSD17B10TSHRHPGDALDH1A1
SCHEMBL6981031 0.89 HSD17B10 (0.64) MAPK10HSD17B10TSHRHPGDALDH1A1
SCHEMBL11949785 0.87 MAPK10 (0.86) MAPK10HSD17B10TSHRHPGDALDH1A1
SCHEMBL11960890 0.86 MAPK10 (0.63) MAPK10HSD17B10TSHRHPGDALDH1A1
SCHEMBL11893723 0.86 TSHR (0.63) MAPK10HSD17B10TSHRHPGDALDH1A1
SCHEMBL1667021 0.86 TSHR (0.63) MAPK10HSD17B10TSHRHPGDALDH1A1
SCHEMBL11949738 0.86 HPGD (0.53) MAPK10HSD17B10TSHRHPGDALDH1A1
SCHEMBL17796206 0.84 MAPK10 (0.66) MAPK10HSD17B10TSHRHPGDALDH1A1
SCHEMBL11949764 0.84 MAPK10 (0.81) MAPK10HSD17B10TSHRHPGDALDH1A1
SCHEMBL11949798 0.84 MAPK10 (0.81) MAPK10HSD17B10TSHRHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8865704-B2 Wnt pathway antagonists SIENA BIOTECH S.P.A. (IT) 2014-10-21 — — US disclosed
US-8865704-B2 Wnt pathway antagonists SIENA BIOTECH S.P.A. (IT) 2014-10-21 — — US disclosed
US-8865704-B2 Wnt pathway antagonists SIENA BIOTECH S.P.A. (IT) 2014-10-21 — — US disclosed
WO-2013177349-A2 QUINAZOLINEDIONES AS TANKYRASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2013-11-28 — — WO disclosed
EP-2485728-B1 WNT PATHWAY ANTAGONISTS SIENA BIOTECH SPA (IT) 2013-07-10 — — EP disclosed
EP-2485728-B1 WNT PATHWAY ANTAGONISTS SIENA BIOTECH SPA (IT) 2013-07-10 — — EP disclosed
EP-2485728-A1 WNT PATHWAY ANTAGONISTS Siena Biotech S.p.a. (IT) 2012-08-15 — — EP disclosed
US-20120196851-A1 WNT PATHWAY ANTAGONISTS SIENA BIOTECH S.P.A. (IT) 2012-08-02 — — US disclosed
US-20120196851-A1 WNT PATHWAY ANTAGONISTS SIENA BIOTECH S.P.A. (IT) 2012-08-02 — — US disclosed
US-20120196851-A1 WNT PATHWAY ANTAGONISTS SIENA BIOTECH S.P.A. (IT) 2012-08-02 — — US disclosed
WO-2011042145-A1 WNT PATHWAY ANTAGONISTS SIENA BIOTECH S.P.A. (IT) 2011-04-14 — — WO disclosed
WO-2011042145-A1 WNT PATHWAY ANTAGONISTS SIENA BIOTECH S.P.A. (IT) 2011-04-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120196851-A1 WNT PATHWAY ANTAGONISTS WNT1, WNT3A, CTNNB1 MAPK10 231/4885HSD17B10 2237/4885TSHR 4195/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.