Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888606 | 0.95 | TNKS (0.48) | TNKSTNKS2PARP1HPGDKDM4E | |
| SCHEMBL1669111 | 0.91 | HPGD (0.46) | TNKSTNKS2PARP1HPGDKDM4E | |
| SCHEMBL1670541 | 0.86 | CHRNA7 (0.44) | TNKSTNKS2PARP1HPGDKDM4E | |
| SCHEMBL6888091 | 0.85 | TNKS (0.51) | TNKSTNKS2PARP1HPGDKDM4E | |
| SCHEMBL6886715 | 0.83 | NPC1 (0.57) | TNKSTNKS2PARP1HPGDKDM4E | |
| SCHEMBL6888887 | 0.83 | CHRNA7 (0.44) | TNKSTNKS2PARP1HPGDKDM4E | |
| SCHEMBL6888303 | 0.80 | CHRNA7 (0.49) | TNKSTNKS2PARP1CHRNA7CHRNA1 | |
| SCHEMBL6888601 | 0.80 | CHRNA7 (0.48) | TNKSTNKS2PARP1HPGDKDM4E | |
| SCHEMBL11922765 | 0.78 | CHRNA7 (0.45) | TNKSTNKS2PARP1HPGDKDM4E | |
| SCHEMBL6888614 | 0.78 | CHRNA7 (0.45) | TNKSTNKS2PARP1CHRNA7CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488520-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | MSD Oss B.V. (NL) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045258-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | N.V. ORGANON (NL) | 2011-04-21 | — | — | WO | disclosed |