SCHEMBL1670541

SCHEMBL1670541

O=c1[nH]c(-c2ccccc2F)nc2ccc(N3CCN4CCCCCCCCCCCCCCCCCCCCCC3CC4)cc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 3/20 0.44
CHRNA1 P02708 1/20 0.44
CHRNB2 P17787 1/20 0.44
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44
CHRNA4 P43681 1/20 0.44
HTR3A P46098 1/20 0.44
AADAT Q8N5Z0 2/20 0.44
KCNH2 Q12809 2/20 0.41
FGFR1 P11362 1/20 0.39
FLT1 P17948 1/20 0.39
MEN1 O00255 2/20 0.38
POLB P06746 2/20 0.38
KMT2A Q03164 2/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
TNKS O95271 1/20 0.38
PARP1 P09874 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6888601 0.94 CHRNA7 (0.48) CHRNA7CHRNA1CHRNB2CHRNB4CHRNA3
SCHEMBL1669111 0.89 HPGD (0.46) CHRNA7MEN1POLBKMT2AKDM4E
SCHEMBL6888303 0.87 CHRNA7 (0.49) CHRNA7CHRNA1CHRNB2CHRNB4CHRNA3
SCHEMBL1669269 0.86 TNKS (0.44) CHRNA7CHRNA1CHRNB2CHRNB4CHRNA3
SCHEMBL6888614 0.83 CHRNA7 (0.45) CHRNA7CHRNA1CHRNB2CHRNB4CHRNA3
SCHEMBL11922765 0.83 CHRNA7 (0.45) CHRNA7CHRNA1CHRNB2CHRNB4CHRNA3
SCHEMBL6888091 0.82 TNKS (0.51) CHRNA7MEN1POLBKMT2AKDM4E
SCHEMBL6888606 0.79 TNKS (0.48) CHRNA7CHRNA1CHRNB2CHRNB4CHRNA3
SCHEMBL6888541 0.77 CHRNA7 (0.46) CHRNA7CHRNA1CHRNB2CHRNB4CHRNA3
SCHEMBL1669065 0.76 IP6K1 (0.60) CHRNA7PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2488520-A1 CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR MSD Oss B.V. (NL) 2012-08-22 EP disclosed
WO-2011045258-A1 CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR N.V. ORGANON (NL) 2011-04-21 WO disclosed