Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | TNKS | O95271 | 4/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888091 | 0.94 | TNKS (0.51) | HPGDTNKSTNKS2PARP1ALDH1A1 | |
| SCHEMBL1669269 | 0.91 | TNKS (0.44) | HPGDTNKSTNKS2PARP1ALDH1A1 | |
| SCHEMBL1670541 | 0.89 | CHRNA7 (0.44) | HPGDTNKSTNKS2PARP1ALDH1A1 | |
| SCHEMBL6888887 | 0.84 | CHRNA7 (0.44) | HPGDTNKSTNKS2PARP1ALDH1A1 | |
| SCHEMBL6888606 | 0.84 | TNKS (0.48) | HPGDTNKSTNKS2PARP1ALDH1A1 | |
| SCHEMBL6886715 | 0.84 | NPC1 (0.57) | HPGDTNKSTNKS2PARP1ALDH1A1 | |
| SCHEMBL6888601 | 0.82 | CHRNA7 (0.48) | HPGDTNKSTNKS2PARP1KDM4E | |
| SCHEMBL6887335 | 0.79 | TNKS (0.48) | HPGDTNKSTNKS2PARP1ALDH1A1 | |
| SCHEMBL1669065 | 0.79 | IP6K1 (0.60) | PARP1CHRNA7 | |
| SCHEMBL6888303 | 0.78 | CHRNA7 (0.49) | TNKSTNKS2PARP1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488520-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | MSD Oss B.V. (NL) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045258-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | N.V. ORGANON (NL) | 2011-04-21 | — | — | WO | disclosed |