Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16691273 | 0.75 | PSEN1 (0.53) | MAPTGRM5KDM4EPSEN1PSEN2 | |
| SCHEMBL16691340 | 0.73 | GRM5 (0.41) | MAPTGRM5CYP2D6 | |
| SCHEMBL16692861 | 0.72 | POLB (0.50) | MAPTGRM5PIK3CA | |
| SCHEMBL16692870 | 0.72 | MAPT (0.38) | MAPTGRM5PSEN1PSEN2APH1B | |
| SCHEMBL16692823 | 0.72 | SMN1; SMN2 (0.43) | MAPTGRM5KDM4EPSEN1PSEN2 | |
| SCHEMBL16691276 | 0.71 | PSEN1 (0.55) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16691277 | 0.70 | PSEN1 (0.49) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16692838 | 0.70 | GRM5 (0.41) | MAPTGRM5CYP2D6 | |
| SCHEMBL30749107 | 0.68 | PSEN1 (0.45) | MAPTGRM5PSEN1PSEN2APH1B | |
| SCHEMBL16692850 | 0.68 | CYP2A13 (0.43) | MAPTCYP2D6KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066697-A1 | FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-05-07 | — | — | WO | disclosed |