Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16692848 | 0.89 | PKM (0.39) | GRM5MAPTMAPK1TNIKALDH1A1 | |
| SCHEMBL16692858 | 0.89 | CYP2C9 (0.43) | MAPTMAPK1TNIKCYP2D6 | |
| SCHEMBL16692838 | 0.88 | GRM5 (0.41) | GRM5MAPTCYP2D6 | |
| SCHEMBL16692866 | 0.87 | TNIK (0.44) | MAPTMAPK1TNIKALDH1A1PKM | |
| SCHEMBL30443099 | 0.87 | TNIK (0.44) | MAPTMAPK1TNIKALDH1A1PKM | |
| SCHEMBL16692850 | 0.86 | CYP2A13 (0.43) | MAPTCYP2D6ALDH1A1GAA | |
| SCHEMBL16692874 | 0.84 | ROCK2 (0.50) | TNIKALDH1A1GAA | |
| SCHEMBL16692826 | 0.84 | TNIK (0.46) | TNIKALDH1A1 | |
| SCHEMBL16692869 | 0.81 | CNR2 (0.44) | MAPTALDH1A1AR | |
| SCHEMBL16692842 | 0.81 | KCNH2 (0.43) | ALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066696-A1 | FUSED MORPHLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-05-07 | — | — | WO | disclosed |
| WO-2015066697-A1 | FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-05-07 | — | — | WO | disclosed |