Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16046551 | 0.88 | GPR35 (0.45) | GPR35HDAC4HDAC6TSHRAKR1B1 | |
| SCHEMBL13725141 | 0.87 | PIM1 (0.45) | GPR35HDAC4HDAC6AKR1B1MAOB | |
| SCHEMBL931539 | 0.85 | MAOB (0.51) | GPR35HDAC4HDAC6TSHRAKR1B1 | |
| SCHEMBL29540395 | 0.83 | GPR35 (0.60) | GPR35HDAC4HDAC6AKR1B1MAOB | |
| SCHEMBL19744146 | 0.83 | GPR35 (0.60) | GPR35HDAC4HDAC6AKR1B1MAOB | |
| SCHEMBL20559444 | 0.83 | MAPT (0.44) | GPR35PTPN11KDM4EALDH1A1MAPT | |
| SCHEMBL19188041 | 0.83 | DHODH (0.41) | GPR35HDAC4HDAC6AKR1B1MAOB | |
| SCHEMBL2303899 | 0.82 | MAOA (0.51) | HDAC4HDAC6TSHRMAOBKDM4E | |
| SCHEMBL16684605 | 0.78 | MAOB (0.51) | TSHRAKR1B1MAOBKDM4EALDH1A1 | |
| SCHEMBL26244513 | 0.77 | AKR1B1 (0.42) | HDAC4HDAC6AKR1B1MAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066371-A1 | SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS | FORUM PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |