Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631618 | 0.88 | POLB (0.61) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL3631622 | 0.88 | POLB (0.61) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL1669408 | 0.85 | POLB (0.79) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL1669410 | 0.85 | POLB (0.79) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL10026668 | 0.81 | RAB9A (0.56) | POLBMEN1KMT2AMAPTRAB9A | |
| SCHEMBL1669357 | 0.79 | SIRT1 (0.74) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL1669361 | 0.79 | SIRT1 (0.74) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL1669490 | 0.78 | MEN1 (0.67) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL1669488 | 0.78 | MEN1 (0.67) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL1672436 | 0.77 | POLB (0.64) | POLBMEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2490696-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISORDERS OF GLUCOSE HOMEOSTASIS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048070-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISORDERS OF GLUCOSE HOMEOSTASIS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-04-28 | — | — | WO | disclosed |