SCHEMBL16694819

SCHEMBL16694819

COC(=O)c1cncc(Br)c1N1CCC(NC(=O)OC(C)(C)C)CC1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CKS1B P61024 1/20 0.46
▸ SKP1 P63208 1/20 0.46
▸ SKP2 Q13309 1/20 0.46
▸ OPRK1 P41145 12/20 0.42
▸ SUV39H2 Q9H5I1 2/20 0.42
▸ CTSK P43235 2/20 0.40
▸ PARP1 P09874 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17965894 0.90 CKS1B (0.49) CKS1BSKP1SKP2OPRK1SUV39H2
SCHEMBL17007074 0.83 CKS1B (0.56) CKS1BSKP1SKP2OPRK1PARP1
SCHEMBL16694507 0.82 SSTR2 (0.52) CKS1BSKP1SKP2OPRK1SUV39H2
SCHEMBL16608976 0.81 CKS1B (0.45) CKS1BSKP1SKP2OPRK1SUV39H2
SCHEMBL21248739 0.79 JAK3 (0.47) CKS1BSKP1SKP2SUV39H2CTSK
SCHEMBL21248737 0.79 JAK3 (0.47) CKS1BSKP1SKP2SUV39H2CTSK
Phosphoric Acid SCHEMBL16694996 0.79 CKS1B (0.51) CKS1BSKP1SKP2OPRK1PARP1
SCHEMBL21056645 0.78 CKS1B (0.50) CKS1BSKP1SKP2OPRK1SUV39H2
SCHEMBL16944494 0.78 OPRK1 (0.71) OPRK1
SCHEMBL24456772 0.78 CKS1B (0.52) CKS1BSKP1SKP2OPRK1SUV39H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3053916-B1 COMPOUND HAVING SOMATOSTATIN RECEPTOR AGONISTIC ACTIVITY AND PHARMACEUTICAL USE THEREOF ONO PHARMACEUTICAL CO (JP) 2019-01-30 — — EP disclosed
US-20180194775-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2018-07-12 — — US disclosed
US-9975904-B2 Compound having agonistic activity on somatostatin receptor, and use thereof for medical purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2018-05-22 — — US disclosed
US-20170183359-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2017-06-29 — — US disclosed
US-9643951-B2 Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2017-05-09 — — US disclosed
US-9630976-B2 Compound having agonistic activity on somatostatin receptor, and use thereof for medical purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2017-04-25 — — US disclosed
US-20160311794-A1 COMPOUND HAVING SOMATOSTATIN RECEPTOR AGONISTIC ACTIVITY AND PHARMACEUTICAL USE THEREOF ONO PHARMACEUTICAL CO., LTD. (JP) 2016-10-27 — — US disclosed
US-20150232478-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2015-08-20 — — US disclosed
EP-2871179-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES ONO Pharmaceutical Co., Ltd. (JP) 2015-05-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170183359-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES SSTR2, SSTR1, SSTR3 CKS1B 4744/4885SKP1 961/4885SKP2 2652/4885
US-20150232478-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES SSTR2, SSTR1, SSTR3 CKS1B 4734/4885SKP1 1112/4885SKP2 2836/4885
US-20160311794-A1 COMPOUND HAVING SOMATOSTATIN RECEPTOR AGONISTIC ACTIVITY AND PHARMACEUTICAL USE THEREOF SSTR1, SSTR2, SSTR3 CKS1B 4574/4885SKP1 1214/4885SKP2 2862/4885
US-20180194775-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES SSTR2, SSTR1, SSTR3 CKS1B 4744/4885SKP1 961/4885SKP2 2652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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