Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 12/20 | 0.85 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709952 | 1.00 | MBOAT4 (0.85) | MBOAT4ITGB3ITGA2BKMT2AMEN1 | |
| SCHEMBL16699286 | 0.91 | MBOAT4 (0.87) | MBOAT4ITGB3ITGA2BOPRK1 | |
| SCHEMBL16718758 | 0.91 | MBOAT4 (0.87) | MBOAT4ITGB3ITGA2BOPRK1 | |
| SCHEMBL19971862 | 0.91 | MBOAT4 (0.87) | MBOAT4ITGB3ITGA2BOPRK1 | |
| SCHEMBL19971870 | 0.90 | MBOAT4 (0.82) | MBOAT4ITGB3ITGA2BOPRK1 | |
| SCHEMBL18166199 | 0.90 | MBOAT4 (0.82) | MBOAT4ITGB3ITGA2BOPRK1 | |
| SCHEMBL19971879 | 0.90 | MBOAT4 (1.00) | MBOAT4ITGB3ITGA2BKMT2AOPRK1 | |
| SCHEMBL18166106 | 0.90 | MBOAT4 (1.00) | MBOAT4ITGB3ITGA2BKMT2AOPRK1 | |
| SCHEMBL18166105 | 0.90 | MBOAT4 (1.00) | MBOAT4ITGB3ITGA2BKMT2AOPRK1 | |
| SCHEMBL19971834 | 0.89 | MBOAT4 (0.84) | MBOAT4ITGB3ITGA2BOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068775-B1 | SUBSTITUTED PIPERIDYL-ETHYL-PYRIMIDINE AS GHRELIN O-ACYL TRANSFERASE INHIBITOR | LILLY CO ELI (US) | 2017-09-06 | — | — | EP | disclosed |
| EP-3068775-B1 | SUBSTITUTED PIPERIDYL-ETHYL-PYRIMIDINE AS GHRELIN O-ACYL TRANSFERASE INHIBITOR | LILLY CO ELI (US) | 2017-09-06 | — | — | EP | disclosed |
| EP-3068775-A1 | SUBSTITUTED PIPERIDYL-ETHYL-PYRIMIDINE AS GHRELIN O-ACYL TRANSFERASE INHIBITOR | Eli Lilly and Company (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073281-A1 | SUBSTITUTED PIPERIDYL-ETHYL-PYRIMIDINE AS GHRELIN O-ACYL TRANSFERASE INHIBITOR | ELI LILLY AND COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |
| WO-2015073281-A1 | SUBSTITUTED PIPERIDYL-ETHYL-PYRIMIDINE AS GHRELIN O-ACYL TRANSFERASE INHIBITOR | ELI LILLY AND COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |
| US-9035051-B1 | Ghrelin O-acyl transferase inhibitor | ELI LILLY AND COMPANY (US) | 2015-05-19 | — | — | US | disclosed |
| US-9035051-B1 | Ghrelin O-acyl transferase inhibitor | ELI LILLY AND COMPANY (US) | 2015-05-19 | — | — | US | disclosed |
| US-20150133474-A1 | GHRELIN O-ACYL TRANSFERASE INHIBITOR | ELI LILLY AND COMPANY | 2015-05-14 | — | — | US | disclosed |
| US-20150133474-A1 | GHRELIN O-ACYL TRANSFERASE INHIBITOR | ELI LILLY AND COMPANY | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133474-A1 | GHRELIN O-ACYL TRANSFERASE INHIBITOR | MBOAT4, DGAT1, MOGAT2 | MBOAT4 1/4885ITGB3 4105/4885ITGA2B 3496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.