Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774435 | 0.94 | MAPT (0.54) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL18153268 | 0.84 | HRH4 (0.41) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL11963431 | 0.82 | GBA1 (0.42) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL3779757 | 0.80 | LMNA (0.55) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL1579732 | 0.79 | GAA (0.40) | MAPTCYP1A2CYP2D6LMNAHTT | |
| SCHEMBL1318180 | 0.79 | MAPT (0.72) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL3719291 | 0.79 | MAPT (0.72) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL18153411 | 0.78 | GBA1 (0.54) | — | |
| SCHEMBL21796761 | 0.78 | LMNA (0.44) | MAPTCYP1A2LMNAHRH4 | |
| SCHEMBL27908906 | 0.78 | KMT2A (0.62) | MAPTCYP1A2CYP2D6LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015069752-A9 | ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015069752-A1 | ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-05-14 | — | — | WO | disclosed |