Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 2/20 | 0.48 |
| ▸ | SKP1 | P63208 | 2/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.48 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADK | P55263 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7774440 | 0.87 | HRH4 (0.55) | LMNAMAP4K4MAPTCKS1BSKP1 | |
| SCHEMBL3991539 | 0.87 | CKS1B (0.50) | LMNAMAP4K4KMT2AMAPTCKS1B | |
| SCHEMBL24851452 | 0.86 | CKS1B (0.49) | LMNAMAP4K4KMT2AMAPTCKS1B | |
| SCHEMBL30162245 | 0.86 | CKS1B (0.49) | LMNAMAP4K4KMT2AMAPTCKS1B | |
| SCHEMBL1280129 | 0.86 | GPR119 (0.56) | LMNAMAP4K4KMT2AMAPTCKS1B | |
| SCHEMBL21796892 | 0.84 | SUV39H2 (0.49) | LMNAMAP4K4KMT2AMAPTCKS1B | |
| SCHEMBL21744944 | 0.84 | CKS1B (0.49) | LMNAMAP4K4KMT2AMAPTCKS1B | |
| SCHEMBL3874309 | 0.83 | KMT2A (0.54) | LMNAMAP4K4KMT2AMAPTCKS1B | |
| SCHEMBL24851168 | 0.83 | CKS1B (0.53) | LMNAMAP4K4KMT2AMAPTCKS1B | |
| SCHEMBL24851765 | 0.83 | GBA1 (0.51) | MAP4K4KMT2ACKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015069752-A9 | ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015069752-A1 | ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-05-14 | — | — | WO | disclosed |
| CN-103181926-B | Broad-spectrum antitumor drug and application thereof | UNIV EAST CHINA SCIENCE & TECH | 2014-11-12 | — | — | CN | disclosed |
| US-8796297-B2 | 4-substituted-2-amino-pyrimidine derivatives | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| CN-103181926-A | Broad-spectrum antitumor drug and application thereof | UNIV EAST CHINA SCIENCE & TECH | 2013-07-03 | — | — | CN | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | LMNA 3883/4885MAP4K4 1955/4885KMT2A 1818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.