SCHEMBL16701415

SCHEMBL16701415

Nc1nc(Cl)cc(N2CCN(CCN3CCOCC3)CC2)n1

nearest known ligand 0.78

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.78
CYP2D6 P10635 1/20 0.78
MAPT P10636 1/20 0.78
CRHBP P24387 1/20 0.52
CRHR2 Q13324 1/20 0.52
KMT2A Q03164 2/20 0.52
HSP90AA1 P07900 1/20 0.50
HSP90AB1 P08238 1/20 0.50
LMNA P02545 1/20 0.45
HRH4 Q9H3N8 2/20 0.44
PIK3CB P42338 1/20 0.44
HRH3 Q9Y5N1 1/20 0.44
RAF1 P04049 1/20 0.43
BRAF P15056 1/20 0.43
ADCY10 Q96PN6 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1028538 0.88 CYP1A2 (1.00) CYP1A2CYP2D6MAPTCRHBPCRHR2
SCHEMBL1024211 0.79 HRH4 (0.70) CYP1A2CYP2D6MAPTKMT2AHRH4
SCHEMBL1318180 0.76 MAPT (0.72) CYP1A2CYP2D6MAPTCRHBPCRHR2
SCHEMBL3719291 0.76 MAPT (0.72) CYP1A2CYP2D6MAPTCRHBPCRHR2
SCHEMBL2804769 0.76 CASP1 (0.59) CYP1A2CYP2D6MAPTKMT2AHRH4
SCHEMBL27825516 0.76 MAPT (0.55) CYP1A2CYP2D6MAPTKMT2AHSP90AB1
SCHEMBL3293436 0.76 CRHBP (0.77) CYP1A2CYP2D6MAPTCRHBPCRHR2
SCHEMBL16711175 0.75 CYP2D6 (0.55) CYP1A2CYP2D6MAPTHSP90AA1HSP90AB1
SCHEMBL2073711 0.75 CYP1A2 (0.54) CYP1A2CYP2D6MAPTKMT2AHSP90AA1
SCHEMBL1320033 0.75 CYP1A2 (0.70) CYP1A2CYP2D6MAPTCRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015069752-A9 ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-07-09 WO disclosed
WO-2015069752-A1 ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-05-14 WO disclosed