SCHEMBL16701734

SCHEMBL16701734

CC(C)(C)OC(=O)N(CCO)Cc1ccccc1F

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 1/20 0.55
RIPK1 Q13546 2/20 0.47
ALDH1A1 P00352 6/20 0.43
KDM4E B2RXH2 4/20 0.43
TSPO P30536 1/20 0.41
MAPT P10636 2/20 0.41
TP53 P04637 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
ATM Q13315 1/20 0.40
HSD17B10 Q99714 2/20 0.40
CTSS P25774 1/20 0.40
CTSK P43235 1/20 0.40
GUSB P08236 1/20 0.39
LMNA P02545 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21574226 0.86 RIPK1 (0.45) SSTR4RIPK1ALDH1A1KDM4ETSPO
SCHEMBL1844901 0.86 SSTR4 (0.55) SSTR4RIPK1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL1802024 0.86 SSTR4 (0.45) SSTR4RIPK1ALDH1A1KDM4ETSPO
SCHEMBL14762235 0.85 SSTR4 (0.52) SSTR4RIPK1ALDH1A1KDM4EHSD17B10
SCHEMBL25516985 0.84 SSTR4 (0.50) SSTR4MEN1KMT2ACTSS
SCHEMBL16701484 0.84 RIPK1 (0.48) SSTR4RIPK1ALDH1A1KDM4ETSPO
SCHEMBL30174644 0.84 SSTR4 (0.50) SSTR4MEN1KMT2ACTSS
SCHEMBL16701459 0.82 RIPK1 (0.41) SSTR4RIPK1ALDH1A1KDM4ETSPO
SCHEMBL19208208 0.82 SSTR4 (0.54) SSTR4RIPK1
SCHEMBL1802560 0.81 SSTR4 (0.43) SSTR4ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210253534-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS CHINA NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH CO., LTD (CN) 2021-08-19 US disclosed
US-11021446-B2 Compositions and methods for modulating farnesoid X receptors NOVARTIS AG (CH) 2021-06-01 US disclosed
US-20200247757-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. 2020-08-06 US disclosed
US-10683271-B2 Compositions and methods for modulating farnesoid X receptors NOVARTIS AG (CH) 2020-06-16 US disclosed
EP-3288948-B1 FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS NOVARTIS AG (CH) 2019-11-20 EP disclosed
US-10351576-B2 Fused tricyclic pyrazole derivatives useful for farnesoid X receptors NOVARTIS AG (CH) 2019-07-16 US disclosed
US-10351576-B2 Fused tricyclic pyrazole derivatives useful for farnesoid X receptors NOVARTIS AG (CH) 2019-07-16 US disclosed
US-20180298018-A1 FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR FARNESOID X RECEPTORS NOVARTIS AG (CH) 2018-10-18 US disclosed
EP-3288948-A1 FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS Novartis AG (CH) 2018-03-07 EP disclosed
EP-3065738-B1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS NOVARTIS AG (CH) 2018-02-28 EP disclosed
US-20170275256-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA THE GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION 2017-09-28 US disclosed
US-9682939-B2 Compositions and methods for modulating farnesoid X receptors NOVARTIS AG (CH) 2017-06-20 US disclosed
US-9682939-B2 Compositions and methods for modulating farnesoid X receptors NOVARTIS AG (CH) 2017-06-20 US disclosed
US-20160340317-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS NOVARTIS AG (CH) 2016-11-24 US disclosed
US-20160340317-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS NOVARTIS AG (CH) 2016-11-24 US disclosed
WO-2016174616-A1 FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS NOVARTIS AG (CH) 2016-11-03 WO disclosed
WO-2016174616-A1 FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS NOVARTIS AG (CH) 2016-11-03 WO disclosed
US-20160272645-A1 Heterocyclic Compounds and Methods of Use MEDIVATION TECHNOLOGIES, INC. (US) 2016-09-22 US disclosed
WO-2015069441-A1 PYRAZOLO-, IMIDAZOLO- AND PYRROLO-PYRIDINE OR -PYRIMIDINE DERIVATIVES AS INHIBITORS O BRUTONS KINASE (BTK) MEDIVATION TECHNOLOGIES, INC. (US) 2015-05-14 WO disclosed
WO-2015069666-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS IRM LLC (BM) 2015-05-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180298018-A1 FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR FARNESOID X RECEPTORS NR1H4, FXR1, GPBAR1 SSTR4 438/4885RIPK1 1952/4885ALDH1A1 3033/4885
US-10351576-B2 Fused tricyclic pyrazole derivatives useful for farnesoid X receptors NR1H4, FXR1, GPBAR1 SSTR4 438/4885RIPK1 1952/4885ALDH1A1 3033/4885
US-11021446-B2 Compositions and methods for modulating farnesoid X receptors NR1H4, GPBAR1, SLC10A1 SSTR4 404/4885RIPK1 3079/4885ALDH1A1 2796/4885
US-20210253534-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS NR1H4, GPBAR1, SLC10A1 SSTR4 404/4885RIPK1 3079/4885ALDH1A1 2796/4885
US-20160272645-A1 Heterocyclic Compounds and Methods of Use BTK, PIK3CD, PIK3CB SSTR4 4641/4885RIPK1 646/4885ALDH1A1 4290/4885
US-20200247757-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS NR1H4, GPBAR1, SLC10A1 SSTR4 404/4885RIPK1 3079/4885ALDH1A1 2796/4885
US-20160340317-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS NR1H4, GPBAR1, SLC10A1 SSTR4 404/4885RIPK1 3079/4885ALDH1A1 2796/4885
US-20170275256-A1 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS NR1H4, GPBAR1, SLC10A1 SSTR4 404/4885RIPK1 3079/4885ALDH1A1 2796/4885
US-10683271-B2 Compositions and methods for modulating farnesoid X receptors NR1H4, GPBAR1, SLC10A1 SSTR4 404/4885RIPK1 3079/4885ALDH1A1 2796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.