Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670343 | 1.00 | HTT (0.45) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL6950561 | 0.86 | ALDH1A1 (0.48) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL6949121 | 0.82 | HTT (0.53) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL7498958 | 0.69 | ALDH1A1 (0.68) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL5062834 | 0.69 | TLR7 (0.41) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL22438726 | 0.68 | DCTPP1 (0.54) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL6949006 | 0.68 | SMN1; SMN2 (0.40) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL10443668 | 0.65 | ALDH1A1 (0.92) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL26102320 | 0.65 | ALDH1A1 (0.45) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL16380992 | 0.65 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308870-A2 | 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses | UCB Pharma S.A. (BE) | 2011-04-13 | — | — | EP | disclosed |