Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 15/20 | 0.70 |
| ▸ | CDK1 | P06493 | 4/20 | 0.70 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.70 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.70 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.70 |
| ▸ | GSK3B | P49841 | 16/20 | 0.62 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5390676 | 0.89 | GSK3B (0.69) | GSK3ACDK1GSK3BCDK2CDK5 | |
| SCHEMBL14553015 | 0.86 | GSK3A (0.58) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL7155632 | 0.83 | GSK3B (0.62) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL10059342 | 0.82 | GSK3A (1.00) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL7126812 | 0.81 | GSK3A (0.64) | GSK3AGSK3BDYRK1A | |
| Bromide SCHEMBL5399700 | 0.79 | GSK3A (0.51) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL7256635 | 0.78 | GSK3A (0.67) | GSK3AGSK3B | |
| SCHEMBL5408575 | 0.78 | GSK3B (0.70) | GSK3ACDK1GSK3BCDK2CDK5 | |
| Hydrochloric Acid SCHEMBL5403658 | 0.76 | GSK3B (0.98) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL7128018 | 0.76 | GSK3A (0.58) | GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029525-B2 | Compositions and methods for inhibiting expression of GSK-3 genes | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-9029525-B2 | Compositions and methods for inhibiting expression of GSK-3 genes | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |