Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 11/20 | 0.64 |
| ▸ | GSK3B | P49841 | 10/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.49 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7128018 | 0.94 | GSK3A (0.58) | GSK3AGSK3BCHEK1FGFR1NEK2 | |
| SCHEMBL5390676 | 0.85 | GSK3B (0.69) | GSK3AGSK3BDYRK1A | |
| SCHEMBL7256635 | 0.84 | GSK3A (0.67) | GSK3AGSK3BFGFR1MAPK1 | |
| SCHEMBL3434404 | 0.82 | POLB (0.48) | GSK3AGSK3BCHEK1FGFR1NEK2 | |
| SCHEMBL16704792 | 0.81 | GSK3A (0.70) | GSK3AGSK3BDYRK1A | |
| SCHEMBL7155632 | 0.80 | GSK3B (0.62) | GSK3AGSK3BDYRK1A | |
| SCHEMBL31221939 | 0.79 | CDK2 (0.58) | GSK3AGSK3BFGFR1DYRK1A | |
| SCHEMBL7135501 | 0.78 | GSK3B (0.64) | GSK3AGSK3BCHEK1FGFR1SGK1 | |
| SCHEMBL7128023 | 0.77 | GSK3B (0.53) | GSK3AGSK3BCHEK1SGK1AXL | |
| SCHEMBL1496202 | 0.77 | DYRK1A (0.47) | GSK3AGSK3BMAPK1DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003045949-A1 | PYRAZOLOPYRIDINE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-05 | — | — | WO | disclosed |