Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 2/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP14 | P50281 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10072262 | 0.92 | EPHX1 (0.40) | ALOX15SMN1; SMN2CTSKCTSLCTSB | |
| SCHEMBL8918588 | 0.86 | AAK1 (0.30) | — | |
| SCHEMBL8915468 | 0.86 | AAK1 (0.30) | — | |
| SCHEMBL18596276 | 0.86 | AAK1 (0.30) | — | |
| SCHEMBL12462455 | 0.80 | TSHR (0.38) | ALOX15SMN1; SMN2HTTTSHR | |
| SCHEMBL12943507 | 0.79 | MMP2 (0.37) | TSHRACACBMMP1MMP2MMP3 | |
| SCHEMBL20643834 | 0.79 | MMP2 (0.33) | ACACBMMP1MMP2MMP3MMP9 | |
| SCHEMBL16215355 | 0.79 | SMN1; SMN2 (0.37) | ALOX15SMN1; SMN2HTTTSHR | |
| SCHEMBL13561478 | 0.79 | SMN1; SMN2 (0.37) | ALOX15SMN1; SMN2HTTTSHR | |
| SCHEMBL21186348 | 0.78 | KDM4E (0.31) | ALOX15SMN1; SMN2MAPTMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2503881-B1 | FUSED TRICYCLIC COMPOUNDS AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | disclosed |