Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 3/20 | 0.37 |
| ▸ | ESR1 | P03372 | 11/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12800994 | 0.89 | TTR (0.35) | TTRERN1ESR1ESR2AR | |
| SCHEMBL1670649 | 0.87 | ESR1 (0.35) | TTRESR1ESR2ARHSP90AB1 | |
| SCHEMBL1670917 | 0.80 | TTR (0.38) | TTRERN1ESR1ESR2HSP90AB1 | |
| SCHEMBL1670802 | 0.78 | TTR (0.34) | TTRESR1ESR2AR | |
| SCHEMBL1670808 | 0.78 | TTR (0.34) | TTRESR1ESR2AR | |
| SCHEMBL1672953 | 0.77 | ESR2 (0.36) | ESR1ESR2ARHSP90AB1NPC1 | |
| SCHEMBL1672952 | 0.77 | ESR2 (0.36) | ESR1ESR2ARHSP90AB1NPC1 | |
| SCHEMBL12801005 | 0.72 | TTR (0.34) | TTRESR1ESR2HSP90AB1 | |
| SCHEMBL11898569 | 0.71 | ERN1 (0.43) | ERN1ESR1ESR2HSP90AB1 | |
| SCHEMBL1670320 | 0.71 | ESR1 (0.34) | TTRESR1ESR2HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |