Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 6/20 | 0.36 |
| ▸ | ESR1 | P03372 | 5/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672953 | 1.00 | ESR2 (0.36) | ESR2ESR1ARHSP90AB1MAPT | |
| SCHEMBL1670649 | 0.90 | ESR1 (0.35) | ESR2ESR1ARHSP90AB1 | |
| SCHEMBL1670945 | 0.86 | BRD4 (0.34) | GAAMAPK1 | |
| SCHEMBL1670948 | 0.86 | BRD4 (0.34) | GAAMAPK1 | |
| SCHEMBL1671020 | 0.82 | ESR1 (0.34) | ESR2ESR1HSP90AB1 | |
| SCHEMBL1671021 | 0.82 | ESR1 (0.34) | ESR2ESR1HSP90AB1 | |
| SCHEMBL1671189 | 0.78 | ERN1 (0.34) | ESR2ESR1AR | |
| SCHEMBL1671187 | 0.78 | ERN1 (0.34) | ESR2ESR1AR | |
| SCHEMBL12800994 | 0.77 | TTR (0.35) | ESR2ESR1ARHSP90AB1 | |
| SCHEMBL1670624 | 0.77 | TTR (0.38) | ESR2ESR1ARHSP90AB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | claimed |