Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | POLQ | O75417 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 2/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.34 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.34 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29349652 | 0.87 | CES2 (0.50) | CES2POLQMGLLPDE2AORAI1 | |
| SCHEMBL496773 | 0.87 | CES2 (0.50) | CES2POLQMGLLPDE2AORAI1 | |
| SCHEMBL29755537 | 0.83 | PDE2A (0.50) | CES2MGLLPDE2AORAI1ORAI2 | |
| SCHEMBL536190 | 0.83 | IDO1 (0.42) | MGLLLIPEORAI1ORAI2ORAI3 | |
| SCHEMBL582110 | 0.83 | PDE2A (0.50) | CES2MGLLPDE2AORAI1ORAI2 | |
| SCHEMBL29825643 | 0.83 | IDO1 (0.42) | MGLLLIPEORAI1ORAI2ORAI3 | |
| SCHEMBL1670723 | 0.81 | CES2 (0.36) | CES2POLQMGLLPDE2ACYP1A1 | |
| SCHEMBL39406 | 0.79 | CES2 (0.43) | CES2ORAI1ORAI2ORAI3TRPV6 | |
| SCHEMBL29395656 | 0.79 | CES2 (0.43) | CES2ORAI1ORAI2ORAI3TRPV6 | |
| SCHEMBL1668958 | 0.79 | MGLL (0.42) | CES2POLQMGLLPDE2AORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485678-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | Cornell University (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011043817-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | CORNELL UNIVERSITY (US) | 2011-04-14 | — | — | WO | disclosed |