Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 15/20 | 0.66 |
| ▸ | NOS3 | P29474 | 13/20 | 0.66 |
| ▸ | NOS2 | P35228 | 8/20 | 0.66 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.59 |
| ▸ | PLAU | P00749 | 1/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL10827683 | 0.79 | NOS3 (0.69) | NOS1NOS3NOS2SLC22A2SLC22A1 | |
| SCHEMBL319881 | 0.79 | NOS1 (0.66) | NOS1NOS3NOS2SLC22A2SLC22A1 | |
| SCHEMBL7403875 | 0.78 | NOS1 (0.64) | NOS1NOS3NOS2SLC22A2SLC22A1 | |
| SCHEMBL10189842 | 0.78 | NOS1 (0.64) | NOS1NOS3NOS2SLC22A2SLC22A1 | |
| Iodide SCHEMBL8122739 | 0.78 | NOS3 (1.00) | NOS1NOS3NOS2SLC22A2SLC22A1 | |
| Iodide SCHEMBL8621155 | 0.77 | NOS1 (0.66) | NOS1NOS3NOS2SLC22A2SLC22A1 | |
| Hydrochloric Acid SCHEMBL2860585 | 0.76 | NOS1 (1.00) | NOS1NOS3NOS2SLC22A2SLC22A1 | |
| SCHEMBL2447318 | 0.75 | SLC22A2 (1.00) | NOS1SLC22A2SLC22A1SLC22A3PLAU | |
| SCHEMBL5005292 | 0.75 | NOS3 (0.67) | NOS1NOS3NOS2 | |
| SCHEMBL5005289 | 0.75 | NOS3 (0.67) | NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150133512-A1 | N-ARYLTRIAZOLE COMPOUNDS AS LPAR ANTAGONISTS | HOFFMANN-LA ROCHE INC. | 2015-05-14 | — | — | US | disclosed |
| US-20150133512-A1 | N-ARYLTRIAZOLE COMPOUNDS AS LPAR ANTAGONISTS | HOFFMANN-LA ROCHE INC. | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133512-A1 | N-ARYLTRIAZOLE COMPOUNDS AS LPAR ANTAGONISTS | LPAR1, LPAR2, LPAR3 | NOS1 3103/4885NOS3 2784/4885NOS2 3044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.