Sugi Predict

Sugi Predict / Compounds / SCHEMBL167083

SCHEMBL167083

SCHEMBL167083

Clc1ncc2cc[nH]c2n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AXL P30530 4/20 0.42
▸ NUDT1 P36639 2/20 0.42
▸ TYRO3 Q06418 1/20 0.41
▸ DYRK1B Q9Y463 1/20 0.41
▸ PRKCI P41743 2/20 0.40
▸ KDM4E B2RXH2 1/20 0.39
▸ CDK8 P49336 1/20 0.39
▸ MAPK1 P28482 4/20 0.38
▸ PIK3CD O00329 1/20 0.38
▸ PIK3CA P42336 1/20 0.38
▸ PIK3CB P42338 1/20 0.38
▸ PIK3CG P48736 1/20 0.38
▸ AHR P35869 3/20 0.38
▸ RIPK1 Q13546 2/20 0.37
▸ APP P05067 1/20 0.35
▸ RPS6KA5 O75582 1/20 0.35
▸ CMA1 P23946 1/20 0.33
▸ F7 P08709 1/20 0.33
▸ LTA4H P09960 1/20 0.33
▸ F3 P13726 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27734027 0.98 AXL (0.41) AXLNUDT1TYRO3DYRK1BPRKCI
SCHEMBL15917037 0.78 MAPK1 (0.47) AXLNUDT1PRKCICDK8MAPK1
SCHEMBL28330507 0.74 AXL (0.42) AXLNUDT1DYRK1BCDK8MAPK1
SCHEMBL29755564 0.74 ULK1 (0.43) AXLNUDT1PRKCICDK8MAPK1
SCHEMBL313807 0.74 ULK1 (0.43) AXLNUDT1PRKCICDK8MAPK1
SCHEMBL28000102 0.74 AXL (0.42) AXLNUDT1PRKCICDK8MAPK1
SCHEMBL1442938 0.74 AXL (0.42) AXLNUDT1PRKCICDK8MAPK1
SCHEMBL4217784 0.74 AXL (0.42) AXLNUDT1PRKCICDK8MAPK1
SCHEMBL28322681 0.74 ADORA3 (0.40) AXLCDK8PIK3CDPIK3CAPIK3CB
Hydrochloric Acid SCHEMBL29247907 0.72 AXL (0.41) AXLNUDT1DYRK1BPRKCICDK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 566 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117903147-A Preparation method of treasipril and intermediate thereof 沈阳药科大学 2024-04-19 — — CN claimed
CN-111072671-A Preparation method of 5-bromo-2-chloro-7H-pyrrolo [2,3-d ] pyrimidine 浙江理工大学 2020-04-28 — — CN claimed
CN-108864057-B JAK and HDAC double-target-point inhibitor containing 4-aminopyrazole structure and preparation method and application thereof 山东大学 2020-03-31 — — CN claimed
CN-110372704-A The synthetic method of chloro- 7H- pyrrolo- [2,3-d] pyrimidine of the bromo- 2- of 5- 南京普锐达医药科技有限公司 2019-10-25 — — CN claimed
CN-104513248-B A kind of purification process of tropsch imatinib intermediate 重庆医药工业研究院有限责任公司 2019-05-24 — — CN claimed
CN-109563098-A The method for preparing chloro- 7H- pyrrolo- [2,3-d] pyrimidine of 4- 斯福瑞（南通）制药有限公司 2019-04-02 — — CN claimed
CN-101233138-A Pyrrolo[2,3-d]pyrimidine derivatives, their intermediates and synthesis PFIZER PROD INC (US) 2008-07-30 — — CN claimed
EP-4745134-A1 PROTEIN ARGINASE METHYLTRANSFERASE-5 INHIBITOR AND MEDICAL USE THEREOF Jiangsu Yahong Meditech Co., Ltd. (CN) 2026-05-20 — — EP disclosed
US-20260116888-A1 CYCLIN-DEPENDENT KINASE INHIBITORS NOVARTIS AG (CH) 2026-04-30 — — US disclosed
US-12612424-B2 HPK1 inhibitors and uses thereof REGOR PHARMACEUTICALS, INC. (US) 2026-04-28 — — US disclosed
US-20260070915-A1 SUBSTITUTED 7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINES AS SELECTIVE CDK2/4 INHIBITORS INCYTE CORP (US) 2026-03-12 — — US disclosed
US-20260042762-A1 MERTK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-02-12 — — US disclosed
US-20260001887-A1 CYCLIN-DEPENDENT KINASE INHIBITORS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2026-01-01 — — US disclosed
US-20050038246-A1 PPAR active compounds PLEXXIKON, INC. 2005-02-17 — — US disclosed
WO-2005009958-A1 PPAR ACTIVE COMPOUNDS PLEXXIKON, INC. (US) 2005-02-03 — — WO disclosed
CN-1128800-C Pyrolo [2,3-d] pyrimidine compounds PFIZER PROD INC (US) 2003-11-26 — — CN disclosed
CN-1125070-C Pyrrolo [2,3-d] pyrmidine compounds PFIZER PROD INC (US) 2003-10-22 — — CN disclosed
US-6635762-B1 Protein tyrosine kinase or Janus Kinase 3 inhibitors; immunosuppressants PFIZER INC. 2003-10-21 — — US disclosed
CN-1305480-A Pyrrolo [2, 3-d ] pyrimidine compounds PFIZER PROD INC (US) 2001-07-25 — — CN disclosed
CN-1305479-A Pyrrolo [2,3-d] pyrmidine compounds PFIZER PROD INC (US) 2001-07-25 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050038246-A1 PPAR active compounds PPARG, PPARD, PPARA AXL 3588/4885NUDT1 2454/4885TYRO3 4624/4885
US-12612424-B2 HPK1 inhibitors and uses thereof NEK11, NEK1, CSNK1A1 AXL 2178/4885NUDT1 1726/4885TYRO3 1825/4885
US-20260070915-A1 SUBSTITUTED 7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINES AS SELECTIVE CDK2/4 INHIBITORS CDK4, CDK2, CCNC AXL 1244/4885NUDT1 1226/4885TYRO3 2798/4885
US-20260116888-A1 CYCLIN-DEPENDENT KINASE INHIBITORS CDK4, CCNC, CDK6 AXL 1608/4885NUDT1 2320/4885TYRO3 3315/4885
US-20260042762-A1 MERTK DEGRADERS AND USES THEREOF MERTK, CRKL, OSTC AXL 180/4885NUDT1 1973/4885TYRO3 856/4885
US-20260001887-A1 CYCLIN-DEPENDENT KINASE INHIBITORS CDK4, CCNC, CDK2 AXL 2346/4885NUDT1 2233/4885TYRO3 3756/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.