Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16653571 | 0.86 | PIM1 (0.39) | PIM1PIM3CLK4MAPTTYMP | |
| SCHEMBL14152978 | 0.79 | MAPT (0.42) | MAPTKDM4EALDH1A1GAAROCK2 | |
| SCHEMBL29848758 | 0.74 | KDM4E (0.43) | MAPTKDM4EALDH1A1GAAPOLB | |
| SCHEMBL10760551 | 0.74 | PIM1 (0.46) | PIM1PIM3CLK4MAPTTYMP | |
| SCHEMBL5862985 | 0.68 | MAOB (0.51) | POLBHPGDL3MBTL1 | |
| SCHEMBL28288419 | 0.67 | MAPT (0.52) | MAPTKDM4EALDH1A1GAANPSR1 | |
| SCHEMBL3976914 | 0.67 | MAPT (0.63) | CLK4MAPTTYMPALDH1A1JAK2 | |
| SCHEMBL692156 | 0.65 | MAPT (0.56) | PIM1PIM3CLK4MAPTTYMP | |
| SCHEMBL8108278 | 0.65 | MAPT (0.47) | MAPTTYMPKDM4EALDH1A1ROCK2 | |
| SCHEMBL8133180 | 0.65 | KDM4E (0.59) | MAPTKDM4EALDH1A1POLBROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115114-B2 | Bromodomain inhibitors | Quanticel Pharmaceuticals, Inc. (US) | 2015-08-25 | — | — | US | disclosed |
| US-9034900-B2 | Bromodomain inhibitors | Quanticel Pharmaceuticals, Inc. (US) | 2015-05-19 | — | — | US | disclosed |