Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3976914 | 0.78 | MAPT (0.63) | MAPTAURKBALDH1A1PARP1JAK2 | |
| SCHEMBL25434885 | 0.73 | AURKA (0.44) | MAPTAURKAAURKBINCENPTHRB | |
| SCHEMBL27739470 | 0.72 | MAPT (1.00) | MAPTAURKAAURKBINCENPTHRB | |
| SCHEMBL8108278 | 0.72 | MAPT (0.47) | MAPTALDH1A1HPGDHSD17B10PARP1 | |
| SCHEMBL10760551 | 0.72 | PIM1 (0.46) | MAPTALDH1A1HPGDHSD17B10PARP1 | |
| SCHEMBL6140775 | 0.72 | MAPT (0.43) | MAPTALDH1A1HPGDHSD17B10PARP1 | |
| SCHEMBL7084711 | 0.72 | MAPT (0.45) | MAPTAURKAAURKBINCENPTHRB | |
| SCHEMBL28988834 | 0.71 | ALDH1A1 (0.50) | MAPTALDH1A1PARP1TDP1LMNA | |
| SCHEMBL25014 | 0.70 | HSD17B10 (0.50) | MAPTTHRBCASP1ALDH1A1HPGD | |
| SCHEMBL29546125 | 0.70 | HSD17B10 (0.50) | MAPTTHRBCASP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120201804-A1 | TISSUE KALLIKREIN FOR THE TREATMENT OF SCHIZOPHRENIA AND BIPOLAR DISORDER | SANOMUNE, INC. (CA) | 2012-08-09 | — | — | US | disclosed |
| EP-2421553-A1 | TISSUE KALLIKREIN FOR THE TREATMENT OF SCHIZOPHRENIA AND BIPOLAR DISORDER | Sanomune Inc. (CA) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121358-A1 | TISSUE KALLIKREIN FOR THE TREATMENT OF SCHIZOPHRENIA AND BIPOLAR DISORDER | SANOMUNE INC. (CA) | 2010-10-28 | — | — | WO | disclosed |
| US-20030216257-A1 | 1-aryl-4-alkyl halide-2(1h)-pyridones and their use as herbicides | BASF AKTIENGESELLSCHAFT (DE) | 2003-11-20 | — | — | US | disclosed |
| EP-0015773-B1 | N-(6-((ACYLAMINOACYLAMINO OR AMINOACYLAMINO)PHENYL) 1,2-DIHYDRO-2-OXONICOTINYL)PENICILLIN COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1983-07-20 | — | — | EP | disclosed |
| US-4278681-A | N-/6-//ACYLAMINOACYLAMINO OR AMINOACYLAMINO/PHENYL/-1,2-DIHYDRO-2-OXONICOTINYL/PENICILLINS | WARNER-LAMBERT CO. (US) | 1981-07-14 | — | — | US | disclosed |
| EP-0015773-A2 | N-(6-((acylaminoacylamino or aminoacylamino)phenyl) 1,2-dihydro-2-oxonicotinyl)penicillin compounds, processes for their production and compositions containing them | WARNER-LAMBERT COMPANY (US) | 1980-09-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216257-A1 | 1-aryl-4-alkyl halide-2(1h)-pyridones and their use as herbicides | CYP1B1, DDT, CYP1A1 | MAPT 4036/4885AURKA 1587/4885AURKB 2919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.