Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | PRKX | P51817 | 1/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.56 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.56 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1568144 | 0.92 | RAB9A (0.64) | TRPV1HIF1ANPC1PAX8KLF5 | |
| SCHEMBL28594259 | 0.84 | HIF1A (0.84) | HIF1ANPC1P2RX7RAB9AALDH1A1 | |
| SCHEMBL3065901 | 0.82 | TRPV1 (0.74) | TRPV1HIF1ANPC1PAX8KLF5 | |
| SCHEMBL16712965 | 0.81 | ROCK2 (0.66) | HIF1AROCK2RPS6KA5MAP4K4PRKCG | |
| SCHEMBL95489 | 0.81 | TRPV1 (0.67) | TRPV1HIF1ANPC1PAX8KLF5 | |
| SCHEMBL3818841 | 0.81 | RAB9A (0.83) | HIF1AROCK2RPS6KA5MAP4K4PRKCG | |
| SCHEMBL4673005 | 0.81 | CDK4 (0.59) | TRPV1GSK3BNPC1RAB9AMEN1 | |
| SCHEMBL4927375 | 0.79 | ACKR3 (0.57) | TRPV1HIF1AROCK2GSK3BROCK1 | |
| SCHEMBL16712962 | 0.78 | MCHR1 (0.68) | ROCK2RPS6KA5MAP4K4PRKCGPRKACA | |
| SCHEMBL5214716 | 0.78 | HIF1A (0.58) | TRPV1HIF1ANPC1PAX8KLF5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617214-B2 | Compounds for cognitive enhancement and methods of use thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2017-04-11 | — | — | US | disclosed |
| US-9617214-B2 | Compounds for cognitive enhancement and methods of use thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2017-04-11 | — | — | US | disclosed |
| US-20160272587-A1 | COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-09-22 | — | — | US | disclosed |
| US-20160272587-A1 | COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-09-22 | — | — | US | disclosed |
| WO-2015070170-A1 | COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272587-A1 | COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF | ROCK1, ROCK2, RHOA | TRPV1 4286/4885HIF1A 1514/4885ROCK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.