Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 9/20 | 0.51 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28950389 | 0.86 | CRACR2A (0.43) | CRACR2AORAI1 | |
| SCHEMBL1667966 | 0.74 | CRACR2A (0.81) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL1671385 | 0.70 | CRACR2A (0.55) | CRACR2AORAI1KCNJ6KCNJ3NPC1 | |
| SCHEMBL28106553 | 0.68 | CES2 (0.46) | NPC1LMNAPKMRAB9ASMN1; SMN2 | |
| SCHEMBL1671387 | 0.67 | CRACR2A (1.00) | CRACR2AORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28065979 | 0.67 | CES2 (0.47) | NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL27563970 | 0.66 | CCNA2 (0.36) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1879322 | 0.66 | CRACR2A (0.67) | CRACR2AORAI1KCNJ6KCNJ3LMNA | |
| SCHEMBL1666818 | 0.65 | CRACR2A (0.58) | CRACR2AORAI1LMNAPKM | |
| Hydrochloric Acid SCHEMBL1668379 | 0.65 | CRACR2A (0.75) | CRACR2AORAI1NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102834382-B | The pyrazole derivatives of calcium channel modulators is activated as calcium release | 理森制药股份公司 | 2016-08-03 | — | — | CN | claimed |
| CN-102834382-B | The pyrazole derivatives of calcium channel modulators is activated as calcium release | 理森制药股份公司 | 2016-08-03 | — | — | CN | disclosed |