Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23078943 | 0.82 | CA1 (0.43) | CASRCA1CA2CA7CA9 | |
| SCHEMBL4956493 | 0.80 | MAPT (0.49) | MAPTCYP1A2CYP2C9CYP2C19ADRB2 | |
| SCHEMBL16715418 | 0.79 | ADRB2 (0.43) | MAPTCYP1A2CYP2C9CYP2C19ADRB2 | |
| SCHEMBL3863528 | 0.76 | VDR (0.47) | MAPK1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4863699 | 0.76 | VDR (0.46) | MAPTCYP1A2CYP2C9CYP2C19ADRB2 | |
| SCHEMBL17920912 | 0.75 | CA1 (0.43) | CASRCA1CA2CA7CA9 | |
| Hydrochloric Acid SCHEMBL3860889 | 0.74 | VDR (0.46) | MAPTCYP1A2CYP2C9CYP2C19ADRB2 | |
| SCHEMBL20788755 | 0.74 | MAPT (0.63) | CASRCA1CA2CA7CA9 | |
| SCHEMBL25343140 | 0.74 | BACE1 (0.55) | CASRCA1CA2CA7CA9 | |
| SCHEMBL26170669 | 0.74 | CA1 (0.55) | CASRCA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150218122-A1 | Process of Producing Cycloalkylcarboxamido-indole Compounds | VERTEX PHARMACEUTICALS INCORPORATED | 2015-08-06 | — | — | US | disclosed |
| US-9035072-B2 | Process of producing cycloalkylcarboxamido-indole compounds | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218122-A1 | Process of Producing Cycloalkylcarboxamido-indole Compounds | CFTR, IDO1, PKD2 | CASR 2078/4885CA1 4780/4885CA2 2044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.