Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165069 | 0.88 | CA2 (0.57) | PTGS2LIMK1CA12CA2NR1H2 | |
| SCHEMBL6742234 | 0.82 | PTGS2 (0.42) | PTGS2CA12CA2 | |
| SCHEMBL6243674 | 0.78 | KCNH2 (0.50) | PTGS2LIMK1NR1H2NR1H3KCNH2 | |
| SCHEMBL145018 | 0.77 | LIMK1 (0.44) | PTGS2LIMK1NR1H2NR1H3KCNH2 | |
| SCHEMBL13742552 | 0.76 | DYRK1A (0.48) | CA12CA2 | |
| SCHEMBL13472079 | 0.75 | CA12 (0.45) | CA12CA2 | |
| SCHEMBL2140712 | 0.73 | PTGS2 (0.53) | PTGS2NR1H2NR1H3KCNH2LOXL2 | |
| SCHEMBL6737344 | 0.72 | CA2 (0.51) | PTGS2CA12CA2 | |
| SCHEMBL3712310 | 0.71 | PI4KA (0.73) | LIMK1PIK3CDPIK3CG | |
| SCHEMBL28846692 | 0.71 | SCD (0.54) | PTGS2CA12CA2KCNH2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611774-A1 | DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-07-10 | — | — | EP | claimed |
| WO-2012030907-A1 | DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-08 | — | — | WO | claimed |