Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.43 |
| ▸ | JAK1 | P23458 | 9/20 | 0.43 |
| ▸ | JAK3 | P52333 | 11/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16718880 | 0.86 | JAK2 (0.39) | JAK2JAK1JAK3TYK2KCNH2 | |
| SCHEMBL16729327 | 0.81 | KDM4E (0.47) | JAK2JAK1JAK3PIK3CDPIK3R1 | |
| SCHEMBL16718875 | 0.77 | KDM4E (0.44) | JAK2JAK1JAK3PIK3CDPIK3R1 | |
| SCHEMBL16729330 | 0.74 | JAK3 (0.47) | JAK2JAK1JAK3 | |
| SCHEMBL16718873 | 0.68 | JAK2 (0.42) | JAK2JAK1JAK3TYK2KCNH2 | |
| SCHEMBL16718838 | 0.67 | KDM4E (0.44) | JAK2JAK1JAK3 | |
| SCHEMBL21585146 | 0.67 | PIK3CG (0.44) | JAK2JAK3PIK3CDPIK3R1PIK3CG | |
| SCHEMBL16619547 | 0.65 | PIK3CG (0.45) | JAK2JAK3PIK3CDPIK3R1PIK3CG | |
| SCHEMBL17657041 | 0.65 | PIK3CG (0.45) | JAK2JAK1JAK3TYK2PIK3CD | |
| SCHEMBL18208430 | 0.64 | PIK3CG (0.44) | JAK2JAK3PIK3CDPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |