Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 11/20 | 0.39 |
| ▸ | JAK3 | P52333 | 11/20 | 0.39 |
| ▸ | JAK1 | P23458 | 7/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16718875 | 0.87 | KDM4E (0.44) | KDM4EHSD17B10JAK2JAK3JAK1 | |
| SCHEMBL16729330 | 0.82 | JAK3 (0.47) | JAK2JAK3JAK1 | |
| SCHEMBL16729327 | 0.81 | KDM4E (0.47) | KDM4EHSD17B10JAK2JAK3JAK1 | |
| SCHEMBL16718880 | 0.79 | JAK2 (0.39) | KDM4EHSD17B10JAK2JAK3JAK1 | |
| SCHEMBL16718861 | 0.78 | ACKR3 (0.45) | JAK2JAK3JAK1USP30 | |
| SCHEMBL16718884 | 0.76 | JAK2 (0.43) | JAK2JAK3JAK1USP30 | |
| SCHEMBL16718864 | 0.75 | GRM4 (0.41) | BTKJAK2JAK3JAK1 | |
| SCHEMBL16718883 | 0.74 | ALDH1A1 (0.43) | KDM4EHSD17B10BTKJAK2JAK1 | |
| SCHEMBL16718850 | 0.73 | GRM4 (0.47) | JAK2JAK3JAK1 | |
| SCHEMBL16718811 | 0.71 | JAK3 (0.42) | KDM4EBTKJAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |