Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 13/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | JAK1 | P23458 | 10/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16718875 | 0.94 | KDM4E (0.44) | KDM4EHSD17B10JAK2JAK3JAK1 | |
| SCHEMBL16729330 | 0.89 | JAK3 (0.47) | JAK2JAK3JAK1 | |
| SCHEMBL16718838 | 0.81 | KDM4E (0.44) | KDM4EHSD17B10JAK2JAK3JAK1 | |
| SCHEMBL16718794 | 0.81 | JAK2 (0.43) | JAK2JAK3JAK1PIK3CDPIK3CG | |
| SCHEMBL16718795 | 0.79 | JAK2 (0.47) | JAK2JAK3JAK1PIK3CDPIK3CG | |
| SCHEMBL16729253 | 0.78 | JAK2 (0.46) | JAK2JAK3JAK1PIK3CDPIK3CG | |
| SCHEMBL16729255 | 0.75 | ACKR3 (0.46) | JAK2JAK3JAK1PIK3CDPIK3CG | |
| SCHEMBL16729338 | 0.75 | ACKR3 (0.46) | JAK2JAK3JAK1PIK3CDPIK3CG | |
| SCHEMBL16729336 | 0.75 | ACKR3 (0.46) | JAK2JAK3JAK1PIK3CDPIK3CG | |
| SCHEMBL16718808 | 0.75 | ATR (0.47) | JAK2JAK3JAK1PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |