Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16718847 | 0.90 | DPP4 (0.38) | DPP4CHRM4JAK2JAK3PANK3 | |
| SCHEMBL16729335 | 0.84 | HSD11B1 (0.45) | HSD11B1FASNDPP4CHRM4JAK2 | |
| SCHEMBL16718933 | 0.78 | HSD11B1 (0.46) | HSD11B1FASNDPP4CHRM4JAK2 | |
| SCHEMBL16729256 | 0.74 | CHRM4 (0.43) | DPP4CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16718884 | 0.70 | JAK2 (0.43) | DPP4CHRM4JAK2JAK3CHRM2 | |
| SCHEMBL16729253 | 0.70 | JAK2 (0.46) | DPP4CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16718831 | 0.69 | JAK2 (0.54) | DPP4CHRM4JAK2JAK3PANK3 | |
| Trifluoroacetic Acid SCHEMBL16718895 | 0.69 | DPP4 (0.49) | DPP4CHRM4JAK2JAK3CHRM2 | |
| SCHEMBL1345454 | 0.69 | JAK2 (0.55) | DPP4CHRM4JAK2JAK3PANK3 | |
| SCHEMBL7078845 | 0.67 | RET (0.57) | DPP4CHRM4JAK2JAK3PANK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |