Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 9/20 | 0.44 |
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | FASN | P49327 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16729335 | 0.84 | HSD11B1 (0.45) | HSD11B1JAK2JAK3JAK1KCNH2 | |
| SCHEMBL16718849 | 0.78 | HSD11B1 (0.40) | HSD11B1JAK2JAK3JAK1KCNH2 | |
| SCHEMBL16729339 | 0.75 | KDM4E (0.49) | HSD11B1JAK2JAK3JAK1IRAK4 | |
| SCHEMBL16718831 | 0.74 | JAK2 (0.54) | JAK2JAK3JAK1KCNH2CHRM4 | |
| SCHEMBL1345454 | 0.73 | JAK2 (0.55) | JAK2JAK3JAK1KCNH2CHRM4 | |
| SCHEMBL19560025 | 0.71 | NTRK1 (0.61) | JAK2IRAK4NTRK1 | |
| SCHEMBL16729256 | 0.71 | CHRM4 (0.43) | JAK2JAK3JAK1KCNH2CHRM4 | |
| SCHEMBL19560176 | 0.71 | NTRK1 (0.61) | JAK2IRAK4NTRK1 | |
| SCHEMBL19560149 | 0.71 | NTRK1 (0.59) | HSD11B1JAK2IRAK4NTRK1 | |
| SCHEMBL16729253 | 0.70 | JAK2 (0.46) | JAK2JAK3JAK1KCNH2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |