Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16729261 | 0.85 | JAK2 (0.44) | JAK2JAK1JAK3CHRM4GRM4 | |
| SCHEMBL16718864 | 0.83 | GRM4 (0.41) | JAK2JAK1JAK3CHRM4GRM4 | |
| SCHEMBL16729338 | 0.79 | ACKR3 (0.46) | JAK2JAK1JAK3CHRM4GRM4 | |
| SCHEMBL16729255 | 0.79 | ACKR3 (0.46) | JAK2JAK1JAK3CHRM4GRM4 | |
| SCHEMBL16729336 | 0.79 | ACKR3 (0.46) | JAK2JAK1JAK3CHRM4GRM4 | |
| SCHEMBL16718874 | 0.78 | GRM4 (0.48) | JAK2JAK1JAK3CHRM4GRM4 | |
| SCHEMBL16718861 | 0.78 | ACKR3 (0.45) | JAK2JAK1JAK3CHRM4GRM4 | |
| SCHEMBL6913383 | 0.77 | PIK3CA (0.52) | IRAK4JAK2JAK1JAK3CHRM4 | |
| SCHEMBL22947094 | 0.77 | KDM4E (0.67) | KDM4EHSD17B10IRAK4HSD11B1NPC1 | |
| SCHEMBL16718898 | 0.76 | CHRM4 (0.50) | JAK2JAK1JAK3CHRM4GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |