SCHEMBL16719152

SCHEMBL16719152

CC(=O)Oc1cc(Cc2ccc(C(=O)O)c(OC(C)=O)c2)ccc1C(=O)O

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFD P00746 2/20 0.76
KDM4E B2RXH2 5/20 0.65
ALDH1A1 P00352 5/20 0.58
HSD17B10 Q99714 3/20 0.58
HPGD P15428 2/20 0.58
USP2 O75604 1/20 0.58
CYP2C19 P33261 1/20 0.58
TSHR P16473 3/20 0.56
PTGS1 P23219 3/20 0.56
ESR1 P03372 2/20 0.56
PTGS2 P35354 2/20 0.56
ITGB3 P05106 1/20 0.56
ITGA2B P08514 1/20 0.56
HMGB1 P09429 1/20 0.56
GGT1 P19440 1/20 0.56
BLM P54132 1/20 0.56
NAPRT Q6XQN6 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
LMNA P02545 1/20 0.54
CYP1A2 P05177 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16719151 0.94 CFD (0.88) CFDKDM4EALDH1A1HSD17B10HPGD
SCHEMBL6403165 0.87 CFD (0.62) CFDKDM4EALDH1A1HSD17B10HPGD
SCHEMBL16719156 0.86 CFD (1.00) CFDKDM4EALDH1A1HSD17B10HPGD
SCHEMBL27623501 0.84 CFD (0.59) CFDKDM4EALDH1A1HSD17B10HPGD
SCHEMBL16719157 0.83 MAPK1 (0.57) CFDKDM4EALDH1A1HSD17B10HPGD
SCHEMBL6866012 0.82 PPARG (0.65) CFDKDM4EALDH1A1HSD17B10HPGD
SCHEMBL178979 0.82 CFD (0.69) CFDKDM4EALDH1A1TSHRPTGS1
SCHEMBL6097736 0.81 CFD (0.52) CFDKDM4EALDH1A1HSD17B10HPGD
SCHEMBL2761803 0.81 KDM4E (0.67) CFDKDM4EALDH1A1HSD17B10HPGD
SCHEMBL29127649 0.81 PPARA (0.75) CFDKDM4EALDH1A1HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3071543-B1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS AURIN BIOTECH INC (CA) 2019-10-02 EP claimed
US-9751824-B2 Acetyl salicyclic acid dimers, synthesis thereof, and uses thereof to prevent and treat complement-mediated disorders AURIN BIOTECH INC. 2017-09-05 US claimed
US-20160297743-A1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS AURIN BIOTECH INC. (CA) 2016-10-13 US claimed
EP-3071543-A1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS Aurin Biotech Inc. (CA) 2016-09-28 EP claimed
WO-2015070354-A1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS AURIN BIOTECH INC. (CA) 2015-05-21 WO claimed
US-20200121697-A1 METHODS FOR DIAGNOSING AND TREATING CACHEXIA AURIN BIOTECH INC. (CA) 2020-04-23 US disclosed
EP-3630121-A1 METHODS FOR DIAGNOSING AND TREATING CACHEXIA Aurin Biotech Inc. (CA) 2020-04-08 EP disclosed
EP-3071543-B1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS AURIN BIOTECH INC (CA) 2019-10-02 EP disclosed
EP-3071543-B1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS AURIN BIOTECH INC (CA) 2019-10-02 EP disclosed
WO-2018218357-A1 METHODS FOR DIAGNOSING AND TREATING CACHEXIA AURIN BIOTECH INC. (CA) 2018-12-06 WO disclosed
US-9751824-B2 Acetyl salicyclic acid dimers, synthesis thereof, and uses thereof to prevent and treat complement-mediated disorders AURIN BIOTECH INC. 2017-09-05 US disclosed
US-9751824-B2 Acetyl salicyclic acid dimers, synthesis thereof, and uses thereof to prevent and treat complement-mediated disorders AURIN BIOTECH INC. 2017-09-05 US disclosed
US-20160297743-A1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS AURIN BIOTECH INC. (CA) 2016-10-13 US disclosed
US-20160297743-A1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS AURIN BIOTECH INC. (CA) 2016-10-13 US disclosed
EP-3071543-A1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS Aurin Biotech Inc. (CA) 2016-09-28 EP disclosed
WO-2015070354-A1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS AURIN BIOTECH INC. (CA) 2015-05-21 WO disclosed