Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.67 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.67 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.67 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.67 |
| ▸ | PRKDC | P78527 | 2/20 | 0.67 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.67 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.67 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.67 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.67 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.67 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.67 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | ATR | Q13535 | 1/20 | 0.61 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.61 |
| ▸ | TEC | P42680 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18068255 | 0.91 | MTOR (0.81) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16719179 | 0.91 | MTOR (0.68) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL20421419 | 0.89 | MTOR (0.57) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL6875392 | 0.88 | MTOR (0.80) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL6877957 | 0.86 | MTOR (0.81) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16730769 | 0.86 | MTOR (0.63) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL18068256 | 0.86 | MTOR (0.67) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16719267 | 0.86 | MTOR (0.64) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL20897325 | 0.86 | MTOR (0.64) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16719264 | 0.85 | MTOR (0.61) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160264570-A1 | METHOD OF BLOCKING TRANSMISSION OF MALARIAL PARASITE | LOYOLA UNIVERSITY OF CHICAGO | 2016-09-15 | — | — | US | disclosed |
| WO-2015073804-A2 | METHOD OF BLOCKING TRANSMISSION OF MALARIAL PARASITE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264570-A1 | METHOD OF BLOCKING TRANSMISSION OF MALARIAL PARASITE | PLK1, TUBA1C, PPT1 | MTOR 320/4885PIK3CA 1958/4885PIK3CD 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.