SCHEMBL16719655

SCHEMBL16719655

C1=C[N]C(c2ccc3ccsc3c2)=C1

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.36
DYRK1A Q13627 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16720450 0.87 DYRK1A (0.50) DYRK1A
SCHEMBL13742552 0.75 DYRK1A (0.48) SIGMAR1DYRK1A
SCHEMBL9464956 0.72 GSTP1 (0.42)
SCHEMBL13472079 0.67 CA12 (0.45) SIGMAR1DYRK1A
SCHEMBL16720406 0.67 BRD4 (0.43)
SCHEMBL10880693 0.66 CYP1A2 (0.37)
SCHEMBL8338224 0.66 CA2 (0.49) SIGMAR1DYRK1A
SCHEMBL3601974 0.65 ALDH1A1 (0.38)
SCHEMBL27764104 0.65 CHRNA7 (0.32) SIGMAR1DYRK1A
SCHEMBL28274290 0.65 DYRK1A (0.40) SIGMAR1DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3068758-A1 EBNA1 INHIBITORS AND THEIR METHOD OF USE The Wistar Institute Of Anatomy And Biology (US) 2016-09-21 EP disclosed
WO-2015073864-A1 EBNA1 INHIBITORS AND THEIR METHOD OF USE THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2015-05-21 WO disclosed