Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ME2 | P23368 | 1/20 | 0.41 |
| ▸ | ME1 | P48163 | 1/20 | 0.41 |
| ▸ | ME3 | Q16798 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719901 | 0.80 | ABL1 (0.44) | ESR2BACE1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2377419 | 0.80 | HDAC4 (0.50) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL9268604 | 0.80 | ABL1 (0.42) | ESR2BACE1SMN1; SMN2TP53KMT2A | |
| SCHEMBL3542668 | 0.80 | ABL1 (0.42) | ESR2BACE1HDAC4HDAC2HDAC8 | |
| SCHEMBL9988102 | 0.79 | BACE1 (0.38) | BACE1NPC1RAB9ATP53KMT2A | |
| SCHEMBL16719637 | 0.79 | ESR1 (0.42) | ESR2SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL9401044 | 0.79 | ABL1 (0.41) | ESR2BACE1TP53KMT2AABL1 | |
| SCHEMBL4932466 | 0.79 | MAPT (0.44) | ESR2SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL6271291 | 0.79 | ABL1 (0.41) | ESR2BACE1HDAC4HDAC2HDAC8 | |
| SCHEMBL16720388 | 0.78 | AURKA (0.39) | SMN1; SMN2RAB9ATP53KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |