Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.44 |
| ▸ | BCR | P11274 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719990 | 0.85 | ABL1 (0.39) | ABL1ABCB1BCRNPC1RAB9A | |
| SCHEMBL2377419 | 0.81 | HDAC4 (0.50) | ABL1ABCB1BCRCYP3A4CYP1A1 | |
| SCHEMBL16719656 | 0.80 | ESR2 (0.47) | ABL1ABCB1BCRTP53SMN1; SMN2 | |
| SCHEMBL16720630 | 0.79 | CYP11B1 (0.47) | CYP3A4CYP1A1CYP1B1 | |
| SCHEMBL16719854 | 0.78 | ABL1 (0.34) | ABL1ABCB1BCRTP53SMN1; SMN2 | |
| SCHEMBL16719523 | 0.76 | HSD17B1 (0.40) | ABL1ABCB1BCRESR2 | |
| SCHEMBL16720192 | 0.76 | CNR1 (0.39) | ABL1ABCB1BCRALOX5 | |
| SCHEMBL17514940 | 0.72 | AKR1C3 (0.44) | ABL1ABCB1BCRCYP3A4CYP1A1 | |
| SCHEMBL17514647 | 0.72 | ABL1 (0.43) | ABL1ABCB1BCRCYP3A4CYP1A1 | |
| SCHEMBL2850768 | 0.71 | KMT2A (0.49) | TP53SMN1; SMN2NPC1MAPK1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |