Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719384 | 0.76 | TGFBR1 (0.36) | KDM4EMAPKAPK2ALDH1A1L3MBTL1TGFBR1 | |
| SCHEMBL16719529 | 0.74 | IDO1 (0.39) | SMN1; SMN2KDM4CKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL28895988 | 0.74 | TGFBR1 (0.45) | KDM4EMAPKAPK2ALDH1A1L3MBTL1TGFBR1 | |
| SCHEMBL3383379 | 0.70 | XDH (0.55) | SMN1; SMN2KDM5AKDM2BKDM4CKDM5B | |
| SCHEMBL28441960 | 0.67 | KDM4C (0.67) | SMN1; SMN2KDM5AKDM2BKDM4CKDM5B | |
| SCHEMBL29723246 | 0.67 | KDM4C (0.67) | SMN1; SMN2KDM5AKDM2BKDM4CKDM5B | |
| SCHEMBL16719820 | 0.67 | ABL1 (0.43) | SMN1; SMN2KDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL16720648 | 0.65 | IDO1 (0.46) | SMN1; SMN2KDM4EALDH1A1TGFBR1POLB | |
| SCHEMBL24573026 | 0.64 | DYRK1A (0.60) | SMN1; SMN2MAP4K4KDM5AKDM4CKDM5B | |
| SCHEMBL12335822 | 0.63 | NPC1 (0.59) | SMN1; SMN2KDM4EKDM1AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105934425-B | EBNA1 inhibitors and methods of use thereof | 威斯塔解剖学和生物学研究所 | 2020-08-07 | — | — | CN | disclosed |
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |