Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.31 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719607 | 0.84 | LRRK2 (0.42) | SMN1; SMN2MAPK11MAPK14CSNK1DLMNA | |
| SCHEMBL2377871 | 0.73 | FYN (0.40) | MAPTSMN1; SMN2LMNANTRK1MEN1 | |
| SCHEMBL5914464 | 0.73 | KDM4E (0.46) | MAPTSMN1; SMN2LATS1LATS2CHRM5 | |
| SCHEMBL16720031 | 0.69 | BRAF (0.40) | MEN1KMT2A | |
| Water SCHEMBL27555359 | 0.67 | MAPT (0.41) | MAPTSMN1; SMN2LATS1LATS2CHRM5 | |
| Water SCHEMBL7844031 | 0.67 | MAPT (0.41) | MAPTSMN1; SMN2LATS1LATS2CHRM5 | |
| SCHEMBL1450726 | 0.66 | — | — | |
| SCHEMBL5256819 | 0.64 | MAPT (0.42) | MAPTSMN1; SMN2LATS1LATS2CHRM5 | |
| SCHEMBL9958013 | 0.63 | MAPT (0.43) | MAPTSMN1; SMN2MAPK14LMNANFATC1 | |
| SCHEMBL31193319 | 0.63 | ADORA2B (0.42) | MAPTSMN1; SMN2LATS1LATS2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |