Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719942 | 0.84 | MAPT (0.40) | SMN1; SMN2LMNANPC1RAB9ACSNK1D | |
| SCHEMBL16720397 | 0.81 | HSD17B1 (0.40) | LRRK2ALDH1A1CYP3A4CYP2C9TSHR | |
| SCHEMBL16720442 | 0.81 | PIM1 (0.37) | LRRK2KDM4EHTR7CLK4HPGD | |
| SCHEMBL27034975 | 0.72 | SMARCA2 (0.41) | LRRK2KDM4ELMNAALDH1A1NPC1 | |
| SCHEMBL16719849 | 0.71 | SQOR (0.44) | POLBKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL16720031 | 0.70 | BRAF (0.40) | POLBMEN1KMT2A | |
| SCHEMBL1450726 | 0.67 | — | — | |
| SCHEMBL19212284 | 0.64 | CYP1A2 (0.33) | LRRK2POLBKDM4ELMNAALDH1A1 | |
| SCHEMBL6456879 | 0.63 | CKS1B (0.41) | LRRK2POLBCKS1BSKP1SKP2 | |
| SCHEMBL5802743 | 0.63 | ADORA1 (0.51) | LRRK2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |