Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 4/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637618 | 0.80 | GSTP1 (0.40) | NPC1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL15190605 | 0.76 | ALDH1A1 (0.39) | NPC1PDE2APDE3BPDE3AKDM4E | |
| SCHEMBL2996550 | 0.72 | PDE10A (0.40) | ADORA2APDE10ANPC1MEN1KMT2A | |
| SCHEMBL16720591 | 0.71 | TYR (0.47) | ADORA2AADORA1AHRBRD4APP | |
| SCHEMBL7084471 | 0.71 | NPC1 (0.58) | ADORA2AADORA1AHRTRPA1CA1 | |
| SCHEMBL3986805 | 0.71 | NPC1 (0.59) | ADORA2AADORA1NPC1CYP2A6MEN1 | |
| SCHEMBL16720408 | 0.71 | BACE1 (0.42) | ADORA2AADORA1PDE10AAHRBRD4 | |
| SCHEMBL12504960 | 0.70 | AR (0.51) | APPNPC1MEN1POLBKMT2A | |
| SCHEMBL16720404 | 0.70 | ADORA2A (0.43) | ADORA2AADORA1PDE10ANPC1MEN1 | |
| SCHEMBL16720353 | 0.70 | HSD17B1 (0.46) | PDE10APOLBLMNANFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |