Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.46 |
| ▸ | PDE4A | P27815 | 5/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | HK2 | P52789 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733057 | 0.87 | CA1 (0.44) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL16720490 | 0.83 | KDM1A (0.43) | TP53CNR2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL28451770 | 0.83 | PDE4A (0.41) | PDE4BPDE4APDE4CPDE4DCA1 | |
| SCHEMBL16719946 | 0.81 | FYN (0.43) | CNR2KDM4EALDH1A1HPGDTUBB1 | |
| Water SCHEMBL28213288 | 0.78 | CA1 (0.57) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL730845 | 0.77 | ALDH1A1 (0.42) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL732633 | 0.76 | KMT2A (0.39) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL5433427 | 0.76 | CA1 (0.59) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL28162734 | 0.74 | CA1 (0.57) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL1299477 | 0.72 | MAPT (0.43) | TP53CA1CA2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |