Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719827 | 0.77 | LRRK2 (0.40) | MAP2K1CDK2PDPK1TGFBR1IKBKE | |
| SCHEMBL16720005 | 0.75 | LRRK2 (0.40) | MAP2K1CDK2PDPK1TGFBR1IKBKE | |
| SCHEMBL16720611 | 0.73 | KCNH2 (0.40) | KDM4ELMNATSHRHTTKMT2A | |
| SCHEMBL16720863 | 0.72 | NR4A2 (0.49) | KDM4ELMNAKMT2A | |
| SCHEMBL2991525 | 0.71 | MAP2K1 (0.71) | MAP2K1MTNR1ACCNE1CDK2CAMKK2 | |
| SCHEMBL16720670 | 0.70 | HTR3A (0.36) | LMNA | |
| SCHEMBL16719970 | 0.69 | LRRK2 (0.39) | MAP2K1CDK2PDPK1TGFBR1IKBKE | |
| SCHEMBL11883907 | 0.68 | MAP2K1 (0.61) | MAP2K1MTNR1ACCNE1CDK2KDM4E | |
| SCHEMBL16719653 | 0.68 | KCNH2 (0.38) | KDM4ELMNAHTT | |
| SCHEMBL16720366 | 0.67 | KCNH2 (0.47) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |