Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | SCN2B | O60939 | 3/20 | 0.43 |
| ▸ | SCN1B | Q07699 | 3/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719653 | 0.86 | KCNH2 (0.38) | KCNH2ALDH1A1RAB9ANPC1NOD2 | |
| SCHEMBL16720863 | 0.84 | NR4A2 (0.49) | KCNH2ALDH1A1L3MBTL1RAB9APOLB | |
| SCHEMBL16720618 | 0.74 | KCNH2 (0.37) | KCNH2ALDH1A1 | |
| SCHEMBL694175 | 0.73 | SCN2B (0.49) | KCNH2SCN2BSCN1BSCN5ASCN9A | |
| SCHEMBL6840250 | 0.71 | RORC (0.57) | ALDH1A1NOTUMRORCNR4A2TNF | |
| SCHEMBL16720670 | 0.69 | HTR3A (0.36) | KCNH2ALDH1A1RAB9ANPC1NOD2 | |
| SCHEMBL16719992 | 0.68 | HPGDS (0.36) | KCNH2KMT2A | |
| SCHEMBL17176663 | 0.68 | HTR3A (0.56) | KCNH2ALDH1A1RAB9ANOTUMRORC | |
| SCHEMBL16720198 | 0.67 | MAP2K1 (0.43) | KMT2A | |
| SCHEMBL17176538 | 0.67 | NR4A2 (0.69) | KCNH2ALDH1A1RAB9APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |