Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4B | O94953 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 6/20 | 0.31 |
| ▸ | METAP1 | P53582 | 6/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15075765 | 0.78 | CYP19A1 (0.54) | CYP19A1METAP2METAP1KDM4ENPC1 | |
| SCHEMBL16719703 | 0.73 | APP (0.37) | KDM4ENPC1RAB9AHDAC6 | |
| SCHEMBL9727720 | 0.70 | APP (0.47) | CYP19A1HDAC6 | |
| SCHEMBL3807869 | 0.69 | ESR1 (0.49) | CYP1A2CYP3A4RAB9ASMN1; SMN2HDAC6 | |
| SCHEMBL16720684 | 0.69 | NPC1 (0.37) | KDM4AKDM4BKDM5CKDM5BCYP19A1 | |
| SCHEMBL4477771 | 0.68 | ALDH1A1 (0.33) | — | |
| SCHEMBL16719735 | 0.67 | METAP1 (0.42) | METAP2METAP1 | |
| SCHEMBL3807944 | 0.67 | HDAC3 (0.50) | CYP19A1KDM4ENPC1CYP1A2CYP3A4 | |
| SCHEMBL16720504 | 0.66 | KDM4A (0.41) | KDM4AKDM4BKDM5CKDM5BMETAP2 | |
| SCHEMBL3145603 | 0.66 | KDM4A (0.38) | KDM4AKDM4BKDM5CKDM5BMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |